After being defeated by Triple H, Kane was forced to unmask on the June 23, 2003, edition of Raw.
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Vacating the WWE Title on the Feb. 13, 1997, edition of Raw, Shawn Michaels affirmed he'd "lost his smile."
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John Cena's loss to The Rock at WrestleMania XXVIII sent his life into a tailspin for an entire year.
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After falling to The Ultimate Warrior at WrestleMania VII, Randy Savage was forced into retirement.
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Bret Hart's controversial defeat at Survivor Series 1997 remains one of the most talked-about incidents in WWE history.
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At WrestleMania XXIV, Shawn Michaels ended the WWE career of "Nature Boy" Ric Flair.
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Batista lost an "I Quit" Match to John Cena at Over the Limit 2010, and actually quit WWE the following night.
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In an emotionally charged battle of brothers, Jeff Hardy brutalized his older sibling at Backlash 2009.
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In their second Show of Shows clash in as many years, The Undertaker put an end to the career of Shawn Michaels at WrestleMania XXVI.
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Hulkamaniacs around the globe were inconsolable when The Undertaker captured Hulk Hogan's WWE Title at Survivor Series 1991.
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In a shocking betrayal, Stephanie McMahon turned on her own father at Armageddon 1999, helping Triple H defeat The Chairman in a No Holds Barred Match.
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After Lay-Cool had imploded, Layla ended the career of her former best friend, Michelle McCool, at Extreme Rules 2011.
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After failing to become WWE Champion in a Steel Cage Match on the March 17, 1997, edition of Raw, Bret "Hit Man" Hart went on a wild, profanity-laden rant.
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Lita's departure from WWE was less than grandiose after Mickie James won her Women's Championship at Survivor Series 2006.
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After Triple H fell to the rampaging Brock Lesnar in the "Perfect Storm" at SummerSlam 2012, many wondered whether The Game was truly over.