Rey Mysterio's quest to regain the World Championship may have suffered a severe setback in Santiago, Chile, on Wednesday night.
 
The injury occurred during Wednesday's live event at Arena Santiago, where Mysterio teamed with Kane against Zack Ryder & Curt Hawkins. During the tag contest, Rey suffered an apparent injury to his right arm -- specifically his bicep. Clearly in pain, the Master of the 619 gutted it out and finished the match, then was quickly examined by WWE athletic trainer Jason Crivello upon leaving the ring.
 
Mysterio flew back to the United States late Wednesday night, and is currently in Gulf Breeze, Fla., waiting to meet with world-renowned surgeon Dr. James Andrews, who will determine the extent of the injury. Regardless of Dr. Andrews' findings, Mysterio has his heart set on competing this Sunday night at No Way Out, where he is scheduled to face Edge for the World Championship.
 
Stay with WWE.com as more updates become available regarding Mysterio's condition.